DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends by means of 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic acid substrates have https://collinxinru.get-blogging.com/28494651/an-unbiased-view-of-real-money-betting