Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals within the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://andrewp541mvd9.pennywiki.com/user